For many, the main draw of Mass Effect is the detailed and thoughtful story. The story takes place several decades from now, when humans have expanded into space and run into several alien species. We have diplomatic ties to some species, and others are less friendly. Commander Shepard, the main character (players may choose gender and appearance), is on a mission to both bring attention to and defeat the mysterious and dangerous Reapers, who appear to be a threat to the whole galaxy. The Reapers are capable of making corpses-human and alien-into a sort of technological zombie, and these zombies, as well as a bug-like species, mercenaries, and "mechs" (a type of robot) make up the main enemies.
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Mass Effect 2 picks up right where the last game left off. While Shepard continues to deal with the impending Reaper problem, he/she must work with a shady figure known as The Illusive Man.
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The themes explored in the Mass Effect series are myriad and complex. The series delves into some extremely heavy thematic material, including, but not limited to, genocide, mental illness, germ warfare, racism, militarism, drug use, and medical experimentation. It also addresses loyalty, love, friendship, self-sacrifice, family, spirituality, and other more positive aspects of life. Most of these ideas are dealt with in a thoughtful and critical way. The game is designed to force the players question their own preconceptions and biases, and it does a good job of it. However, these themes are meant for mature players.